Atriálním natriuretickým peptidem a katecholaminy indukovná lipolýza a genová exprese souvisejících genů v podkožní tukové tkáni u pacientlů s hypo a hyperthyreózou

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000284" target="_blank" >RIV/00216208:11120/07:00000284 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients

Popis výsledku v původním jazyce

Thyroid dysfunction is associated with several abnormalities in intermediary metabolism including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide, however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANPinduced lipolysis as well as in the gene expression of HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and _2AR (_2-adrenergic receptor) in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in13 hypothyroid and 11 hyperthyroid age matched women before and 2-4 months after the normalisation of their thyroid status. A microdialysis study was performed on a subset of 9 hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenali

Název v anglickém jazyce

The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients

Popis výsledku anglicky

Thyroid dysfunction is associated with several abnormalities in intermediary metabolism including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide, however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANPinduced lipolysis as well as in the gene expression of HSL (hormone sensitive lipase), PDE3B (phosphodiesterase 3B), UCP2 (uncoupling protein 2), NPR-A (natriuretic peptide receptor type A) and _2AR (_2-adrenergic receptor) in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in13 hypothyroid and 11 hyperthyroid age matched women before and 2-4 months after the normalisation of their thyroid status. A microdialysis study was performed on a subset of 9 hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenali

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Physiology - Endocrinology and Metabolism

ISSN

0193-1849

e-ISSN

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Svazek periodika

293

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

"E246"-"E251"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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