Účinná léčba dvou pacientů s opsklonem a myoklonem vysokou dávkou konazepamu: GAGAergní hypotéza

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F06%3A00000716" target="_blank" >RIV/00216208:11120/06:00000716 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effective high-dose clonazepam treatment in two patients with opsoclonus and myoclonus: GABA-ergic hypothesis

Popis výsledku v původním jazyce

Opsoclonus - myoclonus syndrome (OMS) is a very rare combination of symptoms usually associated with either malignancy or viral infection. The parainfectious manifestation is usually a self-limiting process. We report on two young adults with OMS whose magnetic resonance imagings of the brain were normal. Single photon emission computed tomography showed reduced perfusion mainly in the right cerebellar hemisphere. Initial treatment with corticosteroids did not accelerate recovery in patients. By contrast, clonazepam in higher doses (up to 12 mg/day) dramatically diminished neurological disability without any usual side-effects. Moreover, symptoms of the patients were closely related to the dose of clonazepam. Clonazepam treatment to enhance GABA-ergicneurotransmission is an option in some OMS patients

Název v anglickém jazyce

Effective high-dose clonazepam treatment in two patients with opsoclonus and myoclonus: GABA-ergic hypothesis

Popis výsledku anglicky

Opsoclonus - myoclonus syndrome (OMS) is a very rare combination of symptoms usually associated with either malignancy or viral infection. The parainfectious manifestation is usually a self-limiting process. We report on two young adults with OMS whose magnetic resonance imagings of the brain were normal. Single photon emission computed tomography showed reduced perfusion mainly in the right cerebellar hemisphere. Initial treatment with corticosteroids did not accelerate recovery in patients. By contrast, clonazepam in higher doses (up to 12 mg/day) dramatically diminished neurological disability without any usual side-effects. Moreover, symptoms of the patients were closely related to the dose of clonazepam. Clonazepam treatment to enhance GABA-ergicneurotransmission is an option in some OMS patients

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Neurology

ISSN

0014-3022

e-ISSN

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Svazek periodika

56

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

3

Strana od-do

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Kód UT WoS článku

000241774500009

EID výsledku v databázi Scopus

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