Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000303" target="_blank" >RIV/00216208:11120/07:00000303 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis

Popis výsledku v původním jazyce

Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimichuman OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibitionof proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the im

Název v anglickém jazyce

Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis

Popis výsledku anglicky

Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimichuman OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibitionof proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the im

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR9072" target="_blank" >NR9072: Úloha neurotransmiterů v mechanismu účinku neopioidních analgetik</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

151

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

73-74

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—