Effects of Viscosupplementation on Tribological Behaviour of Articular Cartilage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU147499" target="_blank" >RIV/00216305:26210/22:PU147499 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/22:10157761 RIV/61989592:15110/22:73617694

Výsledek na webu

<a href="https://www.mdpi.com/2075-4442/10/12/361" target="_blank" >https://www.mdpi.com/2075-4442/10/12/361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/lubricants10120361" target="_blank" >10.3390/lubricants10120361</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Viscosupplementation on Tribological Behaviour of Articular Cartilage

Popis výsledku v původním jazyce

Osteoarthritis (OA) is one of the frequent conditions in the orthopaedic practice. The number of OA patients is increasing and the efficacy of the current treatment methods is relatively low in terms of slowing or even preventing of the disease progression. The current research suggests that the lubrication function of the cartilage depends on its articulating surfaces. These surfaces are characterized by extracellular matrices with a three-dimensional porous structure that ensures a proper lubrication regime to protect the surface against the wear. Viscosupplementation is one of the possible treatments to slow the OA progression. This therapeutic intervention is frequently used in the clinical practice for the knee osteoarthritis. Viscosupplementation can, to a certain extent, supplement the lubrication ability of the cartilage by doping the hyaluronic acid (HA) and thus delay the degradation. However, selection of a proper viscosupplement remains a challenge, both in terms of the correct evaluation of the HA properties and their interaction with different stages of the OA. The viscoupplements differ in their HA molecular weight that may influence the CoF development from both the short term and the long-term perspective. The aim of this study is to analyze the coefficient of friction (CoF) between the real surfaces of a bovine cartilage after applying viscosupplements. The experiments were conducted on a pin-on-plate tribometer with a real bovine cartilage to simulate the lubrication regimes of a human joint. The model joint was doped with 4 different commercially available viscosupplements with different molecular weights and cross-linking of the HA. The OA damage was simulated by using a model synovial fluid with a concentration that corresponds to an OA patient. A compression of the cartilage surface was observed during the experiment and the interstitial fluid drained away from the porous cartilage structure. This, in combination with a migrating contact area

Název v anglickém jazyce

Effects of Viscosupplementation on Tribological Behaviour of Articular Cartilage

Popis výsledku anglicky

Osteoarthritis (OA) is one of the frequent conditions in the orthopaedic practice. The number of OA patients is increasing and the efficacy of the current treatment methods is relatively low in terms of slowing or even preventing of the disease progression. The current research suggests that the lubrication function of the cartilage depends on its articulating surfaces. These surfaces are characterized by extracellular matrices with a three-dimensional porous structure that ensures a proper lubrication regime to protect the surface against the wear. Viscosupplementation is one of the possible treatments to slow the OA progression. This therapeutic intervention is frequently used in the clinical practice for the knee osteoarthritis. Viscosupplementation can, to a certain extent, supplement the lubrication ability of the cartilage by doping the hyaluronic acid (HA) and thus delay the degradation. However, selection of a proper viscosupplement remains a challenge, both in terms of the correct evaluation of the HA properties and their interaction with different stages of the OA. The viscoupplements differ in their HA molecular weight that may influence the CoF development from both the short term and the long-term perspective. The aim of this study is to analyze the coefficient of friction (CoF) between the real surfaces of a bovine cartilage after applying viscosupplements. The experiments were conducted on a pin-on-plate tribometer with a real bovine cartilage to simulate the lubrication regimes of a human joint. The model joint was doped with 4 different commercially available viscosupplements with different molecular weights and cross-linking of the HA. The OA damage was simulated by using a model synovial fluid with a concentration that corresponds to an OA patient. A compression of the cartilage surface was observed during the experiment and the interstitial fluid drained away from the porous cartilage structure. This, in combination with a migrating contact area

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lubricants

ISSN

2075-4442

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

„“-„“

Kód UT WoS článku

000902587100001

EID výsledku v databázi Scopus

2-s2.0-85144836745