A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F21%3A00345360" target="_blank" >RIV/68407700:21220/21:00345360 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26210/21:PU139548

Výsledek na webu

<a href="https://doi.org/10.1016/j.biotri.2021.100166" target="_blank" >https://doi.org/10.1016/j.biotri.2021.100166</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotri.2021.100166" target="_blank" >10.1016/j.biotri.2021.100166</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Popis výsledku v původním jazyce

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to the development of new viscosupplement which would significantly improve the lives of people suffering from osteoarthrosis.

Název v anglickém jazyce

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Popis výsledku anglicky

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to the development of new viscosupplement which would significantly improve the lives of people suffering from osteoarthrosis.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

20301 - Mechanical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biotribology

ISSN

2352-5738

e-ISSN

2352-5738

Svazek periodika

25

Číslo periodika v rámci svazku

2352-5738

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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