A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU139548" target="_blank" >RIV/00216305:26210/21:PU139548 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/21:00345360

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S235257382100007X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S235257382100007X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotri.2021.100166" target="_blank" >10.1016/j.biotri.2021.100166</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Popis výsledku v původním jazyce

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.

Název v anglickém jazyce

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Popis výsledku anglicky

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/GA20-00483S" target="_blank" >GA20-00483S: Vliv viskosuplementace kloubní kapaliny na tření a mazání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biotribology

ISSN

2352-5738

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

100166-100166

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85100750132