Radiation-induced production of PAR-1 and TGF-beta 1 mRNA in lung of C57BI6 and C3H murine strains and influence of pharmacoprophylaxis by ACE inhibitors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A43906709" target="_blank" >RIV/00216208:11120/07:43906709 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.prp.2006.10.006" target="_blank" >http://dx.doi.org/10.1016/j.prp.2006.10.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prp.2006.10.006" target="_blank" >10.1016/j.prp.2006.10.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiation-induced production of PAR-1 and TGF-beta 1 mRNA in lung of C57BI6 and C3H murine strains and influence of pharmacoprophylaxis by ACE inhibitors

Popis výsledku v původním jazyce

Transforming growth factor beta 1 (TGF-beta 1) plays an important role in the development of radiation- and drug-induced organ diseases. Proteinases-activated receptor I (PAR-1) is involved in many pathophysiologic processes after its activation by serine proteases. The aim of the present study was to determine messenger RNA (mRNA) production of TGF-beta 1 and PAR-1 in the lungs after local irradiation. Mice of C5713L/6 and C3H/J strains with different susceptibility to fibrosis development were exposedto a of 15 Gy. Non-irradiated mice of both strains were used as negative controls. Control (irradiated) and irradiated angiotensin-converting enzyme (ACE) inhibitor-treated animals were examined simultaneously. The ACE inhibitor group was given butylaminiperindopril for 9 days after irradiation (15 Gy) at a daily dose of 0.1 or 0.2 mg/kg per rectum. On day 9, all mice were sacrificed, and the production of mRNA TGF-beta 1 and PAR-1 in lung tissue was determined semiquantitatively using

Název v anglickém jazyce

Radiation-induced production of PAR-1 and TGF-beta 1 mRNA in lung of C57BI6 and C3H murine strains and influence of pharmacoprophylaxis by ACE inhibitors

Popis výsledku anglicky

Transforming growth factor beta 1 (TGF-beta 1) plays an important role in the development of radiation- and drug-induced organ diseases. Proteinases-activated receptor I (PAR-1) is involved in many pathophysiologic processes after its activation by serine proteases. The aim of the present study was to determine messenger RNA (mRNA) production of TGF-beta 1 and PAR-1 in the lungs after local irradiation. Mice of C5713L/6 and C3H/J strains with different susceptibility to fibrosis development were exposedto a of 15 Gy. Non-irradiated mice of both strains were used as negative controls. Control (irradiated) and irradiated angiotensin-converting enzyme (ACE) inhibitor-treated animals were examined simultaneously. The ACE inhibitor group was given butylaminiperindopril for 9 days after irradiation (15 Gy) at a daily dose of 0.1 or 0.2 mg/kg per rectum. On day 9, all mice were sacrificed, and the production of mRNA TGF-beta 1 and PAR-1 in lung tissue was determined semiquantitatively using

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathology Research and Practice

ISSN

0344-0338

e-ISSN

—

Svazek periodika

203

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

107-114

Kód UT WoS článku

000244679600007

EID výsledku v databázi Scopus

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