Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002496" target="_blank" >RIV/00216208:11120/10:00002496 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023728:_____/10:#0000025 RIV/00216208:11310/10:10080384

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis

Popis výsledku v původním jazyce

Extrapituitary prolactin (PRL) production is regulated by the alternative promoter which contains functional single nucleotide polymorphism -1149 G/T. G allele of this SNP leads to higher mRNA PRL synthesis in lymphocytes. Polymyositis (PM) and systemicsclerosis (SSc) have been associated with increased serum PRL levels, lymphocytes of patients with SSc produce more PRL mRNA. In our association study we tested 75 patients with SSc, 115 patients with polymyositis/dermatomyositis and 123 healthy individuals for -1149 G/T SNP of the extrapituitary PRL promoter. The genotype and allele distribution did not show any differences in groups of PM, DM and SSc patients compared to healthy individuals. However, we found a significant inverse association betweenTT genotype in SSc patients with disease onset above 45 years compared to individuals with SSc and diseases onset prior 45 years and healthy subjects.

Název v anglickém jazyce

Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis

Popis výsledku anglicky

Extrapituitary prolactin (PRL) production is regulated by the alternative promoter which contains functional single nucleotide polymorphism -1149 G/T. G allele of this SNP leads to higher mRNA PRL synthesis in lymphocytes. Polymyositis (PM) and systemicsclerosis (SSc) have been associated with increased serum PRL levels, lymphocytes of patients with SSc produce more PRL mRNA. In our association study we tested 75 patients with SSc, 115 patients with polymyositis/dermatomyositis and 123 healthy individuals for -1149 G/T SNP of the extrapituitary PRL promoter. The genotype and allele distribution did not show any differences in groups of PM, DM and SSc patients compared to healthy individuals. However, we found a significant inverse association betweenTT genotype in SSc patients with disease onset above 45 years compared to individuals with SSc and diseases onset prior 45 years and healthy subjects.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Rheumatology International

ISSN

0172-8172

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

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Kód UT WoS článku

000283503200027

EID výsledku v databázi Scopus

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