The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10145929" target="_blank" >RIV/00216208:11310/13:10145929 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/13:43906767 RIV/00064173:_____/13:#0000332 RIV/00023728:_____/14:#0003047

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00296-012-2472-7" target="_blank" >http://dx.doi.org/10.1007/s00296-012-2472-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00296-012-2472-7" target="_blank" >10.1007/s00296-012-2472-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Popis výsledku v původním jazyce

Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw allelesand functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw*06 allele and PsV (P (corrected) = 0.0013) that was most prominent in early onset disease subtype (P (corrected) = 0.0013). The association between HLA-Cw*06 and PsA was low (P (corrected) = 0.0585) and restricted to PsA patients with early PsV onset (P (corrected) = 0.0195). We found no association of -1149 G/T P

Název v anglickém jazyce

The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

Popis výsledku anglicky

Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw allelesand functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw*06 allele and PsV (P (corrected) = 0.0013) that was most prominent in early onset disease subtype (P (corrected) = 0.0013). The association between HLA-Cw*06 and PsA was low (P (corrected) = 0.0585) and restricted to PsA patients with early PsV onset (P (corrected) = 0.0195). We found no association of -1149 G/T P

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10618" target="_blank" >NS10618: Vliv polymorfismu genu pro prolaktin a jeho exprese v periferních mononukleárních buňkách na rozvoj autoimunitních chorob ? systémového lupusu erythematodes, zánětlivých kloubních chorob (psoriatická a revmatoidní artritida) a psoriasis vulgaris</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Rheumatology International

ISSN

0172-8172

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

913-919

Kód UT WoS článku

000316971800014

EID výsledku v databázi Scopus

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