Heat-shock protein expression in leukemia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002391" target="_blank" >RIV/00216208:11120/11:00002391 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064173:_____/11:#0000170
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s13277-010-0088-7" target="_blank" >http://dx.doi.org/10.1007/s13277-010-0088-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13277-010-0088-7" target="_blank" >10.1007/s13277-010-0088-7</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Heat-shock protein expression in leukemia
Popis výsledku v původním jazyce
Heat-shock proteins (Hsps) are thought to play a role in the development of cancer and to modulate tumor response to cytotoxic therapy. In this study, Hsp27, Hsp60, Hsp90alpha, and HspBP1 gene expression was investigated in human leukemia cell lines as well as in leukemia cells derived from patients with the onset of the disease. Hsp70 membrane expression and expression of Hsp27, Hsp60, Hsp70, Hsp90alpha, and HspBP1 genes were also tested in samples from leukemia patients. Relative Hsps gene expressionwas examined in human leukemia cell lines and also in patients, using real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). Hsp70 cell surface expression was studied in patients with leukemia onset using flow cytometry. All tested cell lines showed significantly increased expression of Hsp60, Hsp90alpha, and HspBP1 genes compared with a cohort of healthy controls; additionally there was increased Hsp27 expression except for Jurkat and CCRF cells. Significantly
Název v anglickém jazyce
Heat-shock protein expression in leukemia
Popis výsledku anglicky
Heat-shock proteins (Hsps) are thought to play a role in the development of cancer and to modulate tumor response to cytotoxic therapy. In this study, Hsp27, Hsp60, Hsp90alpha, and HspBP1 gene expression was investigated in human leukemia cell lines as well as in leukemia cells derived from patients with the onset of the disease. Hsp70 membrane expression and expression of Hsp27, Hsp60, Hsp70, Hsp90alpha, and HspBP1 genes were also tested in samples from leukemia patients. Relative Hsps gene expressionwas examined in human leukemia cell lines and also in patients, using real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). Hsp70 cell surface expression was studied in patients with leukemia onset using flow cytometry. All tested cell lines showed significantly increased expression of Hsp60, Hsp90alpha, and HspBP1 genes compared with a cohort of healthy controls; additionally there was increased Hsp27 expression except for Jurkat and CCRF cells. Significantly
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Tumour Biology
ISSN
1010-4283
e-ISSN
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Svazek periodika
32
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
12
Strana od-do
33-44
Kód UT WoS článku
000285469700004
EID výsledku v databázi Scopus
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