Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003200" target="_blank" >RIV/00216208:11120/11:00003200 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/11:7109
Výsledek na webu
<a href="http://dx.doi.org/10.3109/03009742.2011.552522" target="_blank" >http://dx.doi.org/10.3109/03009742.2011.552522</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03009742.2011.552522" target="_blank" >10.3109/03009742.2011.552522</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls
Popis výsledku v původním jazyce
Heat shock proteins (Hsps) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The objective of this work was to study Hsps mRNA and protein levels to determine if they can be used to differentitate between rheumatiod arthritis (RA), osteoarthrosis (OA) and healthy controls. Hsp gene expression profiles differ significantly between inflammatory (RA) and non-inflammatory (OA) joint diseases showing significantly increased Hsp27 and Hsp90 mRNA levels in RA synovial tissues. Up-regulated Hsp60 and Hsp90 together with down-regulated Hsp70 and elevated HspBP1/Hsp70 mRNA ratios can be used to differentiate between RA patients and healthy individuals through analysis of peripheral blood samples. Despite increased HspBP1 levels inRA sera, Hsp70 levels and the HspBP1/Hsp70 protein ratio remained identical in the RA patients and healthy individuals, which may contribute to the inhibition of Hsp70 anti-apoptotic activity. Hsp gene expression analysis can be implemen
Název v anglickém jazyce
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls
Popis výsledku anglicky
Heat shock proteins (Hsps) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The objective of this work was to study Hsps mRNA and protein levels to determine if they can be used to differentitate between rheumatiod arthritis (RA), osteoarthrosis (OA) and healthy controls. Hsp gene expression profiles differ significantly between inflammatory (RA) and non-inflammatory (OA) joint diseases showing significantly increased Hsp27 and Hsp90 mRNA levels in RA synovial tissues. Up-regulated Hsp60 and Hsp90 together with down-regulated Hsp70 and elevated HspBP1/Hsp70 mRNA ratios can be used to differentiate between RA patients and healthy individuals through analysis of peripheral blood samples. Despite increased HspBP1 levels inRA sera, Hsp70 levels and the HspBP1/Hsp70 protein ratio remained identical in the RA patients and healthy individuals, which may contribute to the inhibition of Hsp70 anti-apoptotic activity. Hsp gene expression analysis can be implemen
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Scandinavian Journal of Rheumatology
ISSN
0300-9742
e-ISSN
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Svazek periodika
40
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
NO - Norské království
Počet stran výsledku
4
Strana od-do
354-357
Kód UT WoS článku
000295476300005
EID výsledku v databázi Scopus
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