Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002392" target="_blank" >RIV/00216208:11120/11:00002392 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/ijo.2010.112" target="_blank" >http://dx.doi.org/10.1038/ijo.2010.112</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ijo.2010.112" target="_blank" >10.1038/ijo.2010.112</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

Popis výsledku v původním jazyce

Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary interventionon ATM content in human adipose tissue.Design:We performed a multi-phase longitudinal study. A total of 27 obese pre-menopausal women (age 39+/-2 years, body mass index 33.7+/-0.5 kg m(-2)) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosor

Název v anglickém jazyce

Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

Popis výsledku anglicky

Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary interventionon ATM content in human adipose tissue.Design:We performed a multi-phase longitudinal study. A total of 27 obese pre-menopausal women (age 39+/-2 years, body mass index 33.7+/-0.5 kg m(-2)) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosor

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10519" target="_blank" >NS10519: Vztah zastoupení makrofágů a dalších buněčných populací v tukové tkáni k obezitě a jejím metabolickým komplikacím</a><br>

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Obesity

ISSN

0307-0565

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

91-98

Kód UT WoS článku

000286094900012

EID výsledku v databázi Scopus

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