Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43903599" target="_blank" >RIV/00216208:11120/12:43903599 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1210/jc.2011-2380" target="_blank" >http://dx.doi.org/10.1210/jc.2011-2380</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2011-2380" target="_blank" >10.1210/jc.2011-2380</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women

Popis výsledku v původním jazyce

Obesity is associated with altered plasma levels of adipokines involved in the development of insulin resistance and obesity-related metabolic disturbances.Objective:The aim was to investigate diet-induced changes in adipokine production in sc abdominaladipose tissue (SAT) during a 6-month, multiphase, weight-reducing dietary intervention.Design, Setting, Participants, and Interventions:Forty-eight obese women followed a dietary intervention consisting of a very low-calorie diet (VLCD) (1 month), followed by a weight-stabilization (WS) period, which consisted of a low-calorie diet (2 months), and a weight-maintenance diet (3 months).Main Outcome Measures:Before and at the end of the VLCD and WS, samples of plasma and SAT were obtained. In a subgroup of 26 women, secretion of adipokines was determined in SAT explants, and in a subgroup of 22 women, SAT mRNA expression was measured.Results:Body weight decreased and insulin sensitivity increased during the intervention. Plasma levels, SA

Název v anglickém jazyce

Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women

Popis výsledku anglicky

Obesity is associated with altered plasma levels of adipokines involved in the development of insulin resistance and obesity-related metabolic disturbances.Objective:The aim was to investigate diet-induced changes in adipokine production in sc abdominaladipose tissue (SAT) during a 6-month, multiphase, weight-reducing dietary intervention.Design, Setting, Participants, and Interventions:Forty-eight obese women followed a dietary intervention consisting of a very low-calorie diet (VLCD) (1 month), followed by a weight-stabilization (WS) period, which consisted of a low-calorie diet (2 months), and a weight-maintenance diet (3 months).Main Outcome Measures:Before and at the end of the VLCD and WS, samples of plasma and SAT were obtained. In a subgroup of 26 women, secretion of adipokines was determined in SAT explants, and in a subgroup of 22 women, SAT mRNA expression was measured.Results:Body weight decreased and insulin sensitivity increased during the intervention. Plasma levels, SA

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Endocrinology and Metabolism

ISSN

0021-972X

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

"E1176"-"E1181"

Kód UT WoS článku

000306286100012

EID výsledku v databázi Scopus

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