White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002886" target="_blank" >RIV/00216208:11120/11:00002886 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/11:00001135

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jpsychires.2010.04.019" target="_blank" >http://dx.doi.org/10.1016/j.jpsychires.2010.04.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpsychires.2010.04.019" target="_blank" >10.1016/j.jpsychires.2010.04.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Popis výsledku v původním jazyce

White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, oreven represent biological risk factor for BD. To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15e30 years), matched byage and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5 Tesla scanner using a validated emi-quantitative scale. We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. White matter hyperintensities did not meet criteria

Název v anglickém jazyce

White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Popis výsledku anglicky

White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, oreven represent biological risk factor for BD. To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15e30 years), matched byage and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5 Tesla scanner using a validated emi-quantitative scale. We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. White matter hyperintensities did not meet criteria

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NR8786" target="_blank" >NR8786: Detekce neuroanatomických rizikových faktorů pro bipolární poruchu</a><br>

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Psychiatric Research

ISSN

0022-3956

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

76-82

Kód UT WoS článku

000287075200012

EID výsledku v databázi Scopus

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