Upregulation of 11?-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003308" target="_blank" >RIV/00216208:11120/11:00003308 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jsbmb.2011.04.002" target="_blank" >http://dx.doi.org/10.1016/j.jsbmb.2011.04.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jsbmb.2011.04.002" target="_blank" >10.1016/j.jsbmb.2011.04.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Upregulation of 11?-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat

Popis výsledku v původním jazyce

Glucocorticoids exert anti-inflammatory and immunomodulatory effects that may be regulated in part by the activities of the glucocorticoid-activating and -inactivating enzymes, 11?-hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2), respectively. Previous studies have demonstrated that inflammatory bowel diseases in humans and experimental animals upregulate 11HSD1 and downregulate 11HSD2. We investigated whether proinflammatory cytokines modulate colonic 11HSDs as well as whether lymphoidorgans exhibit any 11HSD response to inflammation. Colon tissue explants exposed to tumor necrosis factor ? exhibited an upregulation of 11HSD1 mRNA whereas interleukin 1? downregulated 11HSD2 mRNA. Experimental colitis induced by the intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid stimulated 11HSD1 activity not only in the colon but also in mesenteric lymph nodes and the spleen. Analysis of mRNA for 11HSD1 in colon-draining lymph nodes and the spleen showed that infla

Název v anglickém jazyce

Upregulation of 11?-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat

Popis výsledku anglicky

Glucocorticoids exert anti-inflammatory and immunomodulatory effects that may be regulated in part by the activities of the glucocorticoid-activating and -inactivating enzymes, 11?-hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2), respectively. Previous studies have demonstrated that inflammatory bowel diseases in humans and experimental animals upregulate 11HSD1 and downregulate 11HSD2. We investigated whether proinflammatory cytokines modulate colonic 11HSDs as well as whether lymphoidorgans exhibit any 11HSD response to inflammation. Colon tissue explants exposed to tumor necrosis factor ? exhibited an upregulation of 11HSD1 mRNA whereas interleukin 1? downregulated 11HSD2 mRNA. Experimental colitis induced by the intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid stimulated 11HSD1 activity not only in the colon but also in mesenteric lymph nodes and the spleen. Analysis of mRNA for 11HSD1 in colon-draining lymph nodes and the spleen showed that infla

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Steroid Biochemistry and Molecular Biology

ISSN

0960-0760

e-ISSN

—

Svazek periodika

126

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

19-25

Kód UT WoS článku

000292668100003

EID výsledku v databázi Scopus

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