Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003402" target="_blank" >RIV/00216208:11120/11:00003402 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/11:00061085

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijcard.2011.08.021" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2011.08.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2011.08.021" target="_blank" >10.1016/j.ijcard.2011.08.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis

Popis výsledku v původním jazyce

The study focused on platelet-derived chemokines, platelet factor 4 (PF4,CXCL4) and RANTES (CCL5), in symptomatic degenerative aortic stenosis. Methods The study group was comprised of 124 consecutive patients (mean - SD age 71.6-9.5 years, 63.6% men) being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization. Blood samples were collected from the bulbus of the aorta at the beginning of catheterization. Laboratory values for serum levels of PF4 and RANTES were compared between: i) group A (N = 64) patients with AoS and without coronary artery disease (CAD), ii) group B (N = 60) patients with AoS and with stable CAD, and iii) group C (N = 42) control group; patients without AoS and without CAD. Linear regression analyses were performed to adjust the compared groups for variables that might influence platelet activation. Degenerative AoS without CAD and also with CAD had significantly elevated serum conc

Název v anglickém jazyce

Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis

Popis výsledku anglicky

The study focused on platelet-derived chemokines, platelet factor 4 (PF4,CXCL4) and RANTES (CCL5), in symptomatic degenerative aortic stenosis. Methods The study group was comprised of 124 consecutive patients (mean - SD age 71.6-9.5 years, 63.6% men) being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization. Blood samples were collected from the bulbus of the aorta at the beginning of catheterization. Laboratory values for serum levels of PF4 and RANTES were compared between: i) group A (N = 64) patients with AoS and without coronary artery disease (CAD), ii) group B (N = 60) patients with AoS and with stable CAD, and iii) group C (N = 42) control group; patients without AoS and without CAD. Linear regression analyses were performed to adjust the compared groups for variables that might influence platelet activation. Degenerative AoS without CAD and also with CAD had significantly elevated serum conc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

152

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

3

Strana od-do

273-275

Kód UT WoS článku

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EID výsledku v databázi Scopus

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