Evaluation of lipofuscin-like pigments as an index of lead-induced oxidative damage in the brain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003244" target="_blank" >RIV/00216208:11120/12:00003244 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/12:8014 RIV/00216208:11140/12:10118746 RIV/75010330:_____/12:00009895

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.etp.2010.06.005" target="_blank" >http://dx.doi.org/10.1016/j.etp.2010.06.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etp.2010.06.005" target="_blank" >10.1016/j.etp.2010.06.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of lipofuscin-like pigments as an index of lead-induced oxidative damage in the brain

Popis výsledku v původním jazyce

This study was carried out to investigate the role of lead in the development of oxidative stress in the brain. We examined the rate of lipid peroxidation and we determined lipid fluorescence products (lipofuscin-like pigments - LFP) as a marker of lipidperoxidation after short in vitro incubation of rat brain homogenates with lead acetate (10-2, 10-4, 10-6 M lead acetate, 2 h). Simultaneously we examined by the same method in vivo indices of oxidative stress in brains of mice exposed for 12 weeks to 0.2% lead acetate in drinking water. The results show that the concentration of LFP in rat brain homogenates increased significantly after 2 h incubation with 10-2 M lead acetate as compared to controls (P < 0.0001). This effect was not observed in lowerdoses of lead acetate (10-4 and 10-6 M). After the long-term exposure of mice to 0.2% lead acetate, pronounced accumulation of lead and significantly increased concentration of LFP (P < 0.004) in the brains of exposed animals as compared

Název v anglickém jazyce

Evaluation of lipofuscin-like pigments as an index of lead-induced oxidative damage in the brain

Popis výsledku anglicky

This study was carried out to investigate the role of lead in the development of oxidative stress in the brain. We examined the rate of lipid peroxidation and we determined lipid fluorescence products (lipofuscin-like pigments - LFP) as a marker of lipidperoxidation after short in vitro incubation of rat brain homogenates with lead acetate (10-2, 10-4, 10-6 M lead acetate, 2 h). Simultaneously we examined by the same method in vivo indices of oxidative stress in brains of mice exposed for 12 weeks to 0.2% lead acetate in drinking water. The results show that the concentration of LFP in rat brain homogenates increased significantly after 2 h incubation with 10-2 M lead acetate as compared to controls (P < 0.0001). This effect was not observed in lowerdoses of lead acetate (10-4 and 10-6 M). After the long-term exposure of mice to 0.2% lead acetate, pronounced accumulation of lead and significantly increased concentration of LFP (P < 0.004) in the brains of exposed animals as compared

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/OC%20152" target="_blank" >OC 152: Funkční a morfologická studie plasticity mozku u zdravých a neurodefektních myší za různých podmínek</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Toxicologic Pathology

ISSN

0940-2993

e-ISSN

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Svazek periodika

64

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

51-56

Kód UT WoS článku

000299030400008

EID výsledku v databázi Scopus

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