Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: an efficient approach to biomonitoring

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00011446" target="_blank" >RIV/60076658:12520/10:00011446 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: an efficient approach to biomonitoring

Popis výsledku v původním jazyce

Residual pharmaceuticals are generally recognized as relevant sources of aquatic environmental pollutants. In this study, the effects of carbamazepine (CBZ) on the antioxidant defense system in the brain of rainbowtrout in vitrowere studied. The brain homogenates were incubated with various concentrations of CBZ (1.0 mg l-1, 0.2 mg l-1 or 2.0 mg l-1) for 0, 60, 120 min. After incubation, oxidative stress indices (lipid peroxidation and carbonyl protein), antioxidant enzymes (superoxide dismutase, glutathione reductase and glutathione peroxidase) and nonenzymatic antioxidant (reduced glutathione) in each samples were measured. Based on the results, the brain homogenates performed adaptive responses to CBZ-induced stress at environmental concentration (1.0 mg l-1).With increased CBZ concentrations (0.2 or 2.0 mg l-1), oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, together with the significant inhibition of all antioxidant enzymes activi

Název v anglickém jazyce

Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: an efficient approach to biomonitoring

Popis výsledku anglicky

Residual pharmaceuticals are generally recognized as relevant sources of aquatic environmental pollutants. In this study, the effects of carbamazepine (CBZ) on the antioxidant defense system in the brain of rainbowtrout in vitrowere studied. The brain homogenates were incubated with various concentrations of CBZ (1.0 mg l-1, 0.2 mg l-1 or 2.0 mg l-1) for 0, 60, 120 min. After incubation, oxidative stress indices (lipid peroxidation and carbonyl protein), antioxidant enzymes (superoxide dismutase, glutathione reductase and glutathione peroxidase) and nonenzymatic antioxidant (reduced glutathione) in each samples were measured. Based on the results, the brain homogenates performed adaptive responses to CBZ-induced stress at environmental concentration (1.0 mg l-1).With increased CBZ concentrations (0.2 or 2.0 mg l-1), oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, together with the significant inhibition of all antioxidant enzymes activi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

<a href="/cs/project/SP%2F2E7%2F229%2F07" target="_blank" >SP/2E7/229/07: Antropogenní tlaky na stav půd, vodní zdroje a vodní ekosystémy v české části mezinárodního povodí Labe</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000284024200003

EID výsledku v databázi Scopus

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