Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00011403" target="_blank" >RIV/60076658:12520/10:00011403 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine

Popis výsledku v původním jazyce

The chronic toxic effects of carbamazepine (CBZ) on rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 ?g.l-1, 0.2 mg l-1 and 2.0 mg.l-1) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg.l-1), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 ?g.l-1, 0.2 mg.l-1), the antioxidant enzyme activities wereinduced slightly, except catalase, while at the highest concentration (2.0 mg.l-1) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibitionof antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na+-K+-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg.l-1), compared with the control.

Název v anglickém jazyce

Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine

Popis výsledku anglicky

The chronic toxic effects of carbamazepine (CBZ) on rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 ?g.l-1, 0.2 mg l-1 and 2.0 mg.l-1) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg.l-1), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 ?g.l-1, 0.2 mg.l-1), the antioxidant enzyme activities wereinduced slightly, except catalase, while at the highest concentration (2.0 mg.l-1) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibitionof antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na+-K+-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg.l-1), compared with the control.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

<a href="/cs/project/SP%2F2E7%2F229%2F07" target="_blank" >SP/2E7/229/07: Antropogenní tlaky na stav půd, vodní zdroje a vodní ekosystémy v české části mezinárodního povodí Labe</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000277524000002

EID výsledku v databázi Scopus

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