Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43896089" target="_blank" >RIV/00216208:11120/12:43896089 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/12:43913771

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1399-5618.2012.01013.x" target="_blank" >10.1111/j.1399-5618.2012.01013.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment

Popis výsledku v původním jazyce

Hippocampal volume decrease associated with illness burden is among the most replicated findings in unipolar depression. The absence of hippocampal volume changes in most studies of individuals with bipolar disorder (BD) may reflect neuroprotective effects of lithium (Li). Methods: We recruited 17 BD patients from specialized Li clinics, with at least two years of regularly monitored Li treatment (Li group), and compared them to 12 BD participants with < 3 months of lifetime Li exposure and no Li treatment within two years prior to the scanning (non-Li group) and 11 healthy controls. All BD patients had at least 10 years of illness and five episodes. We also recruited 13 Li-na?ve, young BD participants (15-30 years of age) and 18 sex- and age-matched healthy controls. We compared hippocampal volumes obtained from 1.5-T magnetic resonance imaging (MRI) scans using optimized voxel-based morphometry with small volume correction. Results: The non-Li group had smaller left hippocampal volum

Název v anglickém jazyce

Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment

Popis výsledku anglicky

Hippocampal volume decrease associated with illness burden is among the most replicated findings in unipolar depression. The absence of hippocampal volume changes in most studies of individuals with bipolar disorder (BD) may reflect neuroprotective effects of lithium (Li). Methods: We recruited 17 BD patients from specialized Li clinics, with at least two years of regularly monitored Li treatment (Li group), and compared them to 12 BD participants with < 3 months of lifetime Li exposure and no Li treatment within two years prior to the scanning (non-Li group) and 11 healthy controls. All BD patients had at least 10 years of illness and five episodes. We also recruited 13 Li-na?ve, young BD participants (15-30 years of age) and 18 sex- and age-matched healthy controls. We compared hippocampal volumes obtained from 1.5-T magnetic resonance imaging (MRI) scans using optimized voxel-based morphometry with small volume correction. Results: The non-Li group had smaller left hippocampal volum

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bipolar Disorders

ISSN

1398-5647

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

261-270

Kód UT WoS článku

000303438000005

EID výsledku v databázi Scopus

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