Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908343" target="_blank" >RIV/00216208:11120/14:43908343 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/14:43914538

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response

Popis výsledku v původním jazyce

Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this association reflects direct neurochemical effects of Li or indirect effects secondary to treatment or prevention of episodes of bipolar disorder (BD). To address this knowledge gap, we compared manually traced hippocampal volumes in 37 BD patients with at least 2 years of Li treatment (Li group), 19 BD patients with <3 months of lifetime Li exposure over 2 years ago (non-Li group) and 50 healthy controls. All BD participants were followed prospectively and had at least 10 years of illness and a minimum of five episodes. We established illness course and long-term treatment response toLi using National Institute of Mental Health (NIMH) life charts. Results The non-Li group had smaller hippocampal volumes than the controls or the Li group (F-2,F-102=4.97, p=0.009). However, the time spent in a mood episode on the curren

Název v anglickém jazyce

Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response

Popis výsledku anglicky

Neuroimaging studies have demonstrated an association between lithium (Li) treatment and brain structure in human subjects. A crucial unresolved question is whether this association reflects direct neurochemical effects of Li or indirect effects secondary to treatment or prevention of episodes of bipolar disorder (BD). To address this knowledge gap, we compared manually traced hippocampal volumes in 37 BD patients with at least 2 years of Li treatment (Li group), 19 BD patients with <3 months of lifetime Li exposure over 2 years ago (non-Li group) and 50 healthy controls. All BD participants were followed prospectively and had at least 10 years of illness and a minimum of five episodes. We established illness course and long-term treatment response toLi using National Institute of Mental Health (NIMH) life charts. Results The non-Li group had smaller hippocampal volumes than the controls or the Li group (F-2,F-102=4.97, p=0.009). However, the time spent in a mood episode on the curren

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

AN - Psychologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychological Medicine

ISSN

0033-2917

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

507-517

Kód UT WoS článku

000330592300006

EID výsledku v databázi Scopus

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