Impact of psychotropic drugs on adult hippocampal neurogenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43905989" target="_blank" >RIV/00216208:11120/12:43905989 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/12:43913772

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neures.2012.02.014" target="_blank" >http://dx.doi.org/10.1016/j.neures.2012.02.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neures.2012.02.014" target="_blank" >10.1016/j.neures.2012.02.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of psychotropic drugs on adult hippocampal neurogenesis

Popis výsledku v původním jazyce

This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation thanthe performance of cognitive tasks. In this review we provide some evidence for this assumption

Název v anglickém jazyce

Impact of psychotropic drugs on adult hippocampal neurogenesis

Popis výsledku anglicky

This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation thanthe performance of cognitive tasks. In this review we provide some evidence for this assumption

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10378" target="_blank" >NS10378: Sexuální rozdíly v účincích 3,4-methylendioxymetamfetaminu (MDMA) na kognitivní funkce, neurogenzi a farmakokinetické parametry</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Research

ISSN

0168-0102

e-ISSN

—

Svazek periodika

73

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

93-98

Kód UT WoS článku

000304520200001

EID výsledku v databázi Scopus

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