Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBP delta) CpG island in breast cancer is associated with metastatic relapse

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906430" target="_blank" >RIV/00216208:11120/12:43906430 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/12:43906430

Výsledek na webu

<a href="http://dx.doi.org/10.1038/bjc.2012.308" target="_blank" >http://dx.doi.org/10.1038/bjc.2012.308</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bjc.2012.308" target="_blank" >10.1038/bjc.2012.308</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBP delta) CpG island in breast cancer is associated with metastatic relapse

Popis výsledku v původním jazyce

The CCAAT/enhancer binding protein delta (CEBP delta) is a member of a highly conserved family of basic region leucine zipper transcription factors. It has properties consistent with a tumour suppressor; however, other data suggest that CEBP delta may beinvolved in the metastatic process. METHODS: We analysed the expression of CEBP delta and the methylation status of the CpG island in human breast cancer cell lines, in 107 archival cases of primary breast cancer and in two series of metastatic breast cancers using qPCR and pyrosequencing. RESULTS: Expression of CEBP delta is downregulated in primary breast cancer by site-specific methylation in the CEBP delta CpG island. Expression is also downregulated in 50% of cases during progression from primarycarcinoma to metastatic lesions. The CEBP delta CpG island is methylated in 81% metastatic breast cancer lesions, while methylation in the CEBP delta CpG island in primary cancers is associated with increased risk of relapse and metastasi

Název v anglickém jazyce

Site-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBP delta) CpG island in breast cancer is associated with metastatic relapse

Popis výsledku anglicky

The CCAAT/enhancer binding protein delta (CEBP delta) is a member of a highly conserved family of basic region leucine zipper transcription factors. It has properties consistent with a tumour suppressor; however, other data suggest that CEBP delta may beinvolved in the metastatic process. METHODS: We analysed the expression of CEBP delta and the methylation status of the CpG island in human breast cancer cell lines, in 107 archival cases of primary breast cancer and in two series of metastatic breast cancers using qPCR and pyrosequencing. RESULTS: Expression of CEBP delta is downregulated in primary breast cancer by site-specific methylation in the CEBP delta CpG island. Expression is also downregulated in 50% of cases during progression from primarycarcinoma to metastatic lesions. The CEBP delta CpG island is methylated in 81% metastatic breast cancer lesions, while methylation in the CEBP delta CpG island in primary cancers is associated with increased risk of relapse and metastasi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Cancer

ISSN

0007-0920

e-ISSN

—

Svazek periodika

107

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

732-738

Kód UT WoS článku

000307770300022

EID výsledku v databázi Scopus

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