Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906592" target="_blank" >RIV/00216208:11120/12:43906592 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/12:43913773

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls

Popis výsledku v původním jazyce

Background: Inflammatory immune processes have been clearly implicated in the etiopathology of schizophrenia. There are, however, only limited data dealing with immune parameters in the first episode patients with schizophrenia and the course of these parameters during treatment. Subjects and Methods: The presented study compared plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-alpha in 25 patients with the first episode of schizophrenia with the minimal exposition of antipsychotics before and after treatment and with age and sex matched group of healthy volunteers. Changes in plasma cytokine levels were investigated after 4 weeks of treatment in relationship with the therapeutic outcome. Results: Our results show significantly increased plasmalevels of IL-6 (p <= 0.001) and TNF-alpha (p <= 0.001) in patients at the admission in comparison with healthy volunteers. After 4 weeks of the treatment the PANSS score decreased (p <= 0.001), concurrently the plasma level of IL-6 decre

Název v anglickém jazyce

Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls

Popis výsledku anglicky

Background: Inflammatory immune processes have been clearly implicated in the etiopathology of schizophrenia. There are, however, only limited data dealing with immune parameters in the first episode patients with schizophrenia and the course of these parameters during treatment. Subjects and Methods: The presented study compared plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-alpha in 25 patients with the first episode of schizophrenia with the minimal exposition of antipsychotics before and after treatment and with age and sex matched group of healthy volunteers. Changes in plasma cytokine levels were investigated after 4 weeks of treatment in relationship with the therapeutic outcome. Results: Our results show significantly increased plasmalevels of IL-6 (p <= 0.001) and TNF-alpha (p <= 0.001) in patients at the admission in comparison with healthy volunteers. After 4 weeks of the treatment the PANSS score decreased (p <= 0.001), concurrently the plasma level of IL-6 decre

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13843" target="_blank" >NT13843: Vliv imunitní dysregulace a latentní toxoplazmózy na morfologické změny mozku u schizofrenie: animální modely a prospektivní volumometrická studie u pacientů.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatria Danubina

ISSN

0353-5053

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

4

Strana od-do

"S153"-"S156"

Kód UT WoS článku

000309094600035

EID výsledku v databázi Scopus

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