Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10364864" target="_blank" >RIV/00216208:11150/17:10364864 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/17:10364864 RIV/00179906:_____/17:10364864

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s00403-017-1785-5" target="_blank" >http://link.springer.com/article/10.1007/s00403-017-1785-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00403-017-1785-5" target="_blank" >10.1007/s00403-017-1785-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis

Popis výsledku v původním jazyce

Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-alpha, CRP, and IL-6. The range of PASI score in psoriatic patients was 10-34 (median 19). In the patients, we found significantly elevated levels (p &lt; 0.001) of cfDNA, nucleosomes, TNF-alpha, CRP, and IL-6. We did not find any significant relationship between the analyzed parameters in either group (i.e., experimental or control). Elevated levels of the biomarkers of inflammation (TNF-alpha, CRP, and IL-6) and the indicators of apoptosis (cfDNA, circulating nucleosomes) proved that exacerbated psoriasis vulgaris is associated with a high degree of systemic inflammatory responses and dysregulated apoptotic pathways.

Název v anglickém jazyce

Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis

Popis výsledku anglicky

Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-alpha, CRP, and IL-6. The range of PASI score in psoriatic patients was 10-34 (median 19). In the patients, we found significantly elevated levels (p &lt; 0.001) of cfDNA, nucleosomes, TNF-alpha, CRP, and IL-6. We did not find any significant relationship between the analyzed parameters in either group (i.e., experimental or control). Elevated levels of the biomarkers of inflammation (TNF-alpha, CRP, and IL-6) and the indicators of apoptosis (cfDNA, circulating nucleosomes) proved that exacerbated psoriasis vulgaris is associated with a high degree of systemic inflammatory responses and dysregulated apoptotic pathways.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Dermatological Research

ISSN

0340-3696

e-ISSN

—

Svazek periodika

309

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

815-821

Kód UT WoS článku

000414651400005

EID výsledku v databázi Scopus

2-s2.0-85031398768