Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906840" target="_blank" >RIV/00216208:11120/12:43906840 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cellimm.2012.06.004" target="_blank" >http://dx.doi.org/10.1016/j.cellimm.2012.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cellimm.2012.06.004" target="_blank" >10.1016/j.cellimm.2012.06.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection

Popis výsledku v původním jazyce

Invariant natural killer T (iNKT) cells, CD1d restricted T cells, are involved in the immune responses against various infection agents. Here we describe their behavior during reactivation of human herpes simplex virus (HSV). iNKT cells exhibit only discrete changes, which however, reached statistically significant level due to the relatively large patient group. Higher percentage of iNKT cells express NKG2D. iNKT cells down-regulate NKG2A in a subset of patients. Finally, iNKT cells enhance their capacity to produce TNF-alpha. Our data suggests that iNKT cells are involved in the immune response against HSV and contribute mainly to its early, innate phase.

Název v anglickém jazyce

Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection

Popis výsledku anglicky

Invariant natural killer T (iNKT) cells, CD1d restricted T cells, are involved in the immune responses against various infection agents. Here we describe their behavior during reactivation of human herpes simplex virus (HSV). iNKT cells exhibit only discrete changes, which however, reached statistically significant level due to the relatively large patient group. Higher percentage of iNKT cells express NKG2D. iNKT cells down-regulate NKG2A in a subset of patients. Finally, iNKT cells enhance their capacity to produce TNF-alpha. Our data suggests that iNKT cells are involved in the immune response against HSV and contribute mainly to its early, innate phase.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellular Immunology

ISSN

0008-8749

e-ISSN

—

Svazek periodika

278

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

16-20

Kód UT WoS článku

000311812000003

EID výsledku v databázi Scopus

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