Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4 bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906765" target="_blank" >RIV/00216208:11120/13:43906765 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00392579 RIV/00023752:_____/13:43914167 RIV/00216208:11110/13:00011958 RIV/00064165:_____/13:00011958

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >http://dx.doi.org/10.1007/s00213-012-2797-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >10.1007/s00213-012-2797-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4 bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Popis výsledku v původním jazyce

Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. MATERIALS AND METHODS: Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamineand its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. RESULTS: 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence

Název v anglickém jazyce

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4 bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Popis výsledku anglicky

Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. MATERIALS AND METHODS: Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamineand its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. RESULTS: 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

0033-3158

e-ISSN

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Svazek periodika

225

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

75-93

Kód UT WoS článku

000313163900007

EID výsledku v databázi Scopus

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