Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43896716" target="_blank" >RIV/60461373:22310/13:43896716 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >http://dx.doi.org/10.1007/s00213-012-2797-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-012-2797-7" target="_blank" >10.1007/s00213-012-2797-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Popis výsledku v původním jazyce

Rationale and objectives Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo- 2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Materials and methods Locomotor effects, prepulse inhibition (PPI) of acoustic startlereaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. Results 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as i

Název v anglickém jazyce

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

Popis výsledku anglicky

Rationale and objectives Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo- 2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Materials and methods Locomotor effects, prepulse inhibition (PPI) of acoustic startlereaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound. Results 2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as i

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT13843" target="_blank" >NT13843: Vliv imunitní dysregulace a latentní toxoplazmózy na morfologické změny mozku u schizofrenie: animální modely a prospektivní volumometrická studie u pacientů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

1432-2072

e-ISSN

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Svazek periodika

225

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

18

Strana od-do

75-93

Kód UT WoS článku

000313163900007

EID výsledku v databázi Scopus

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