The Oxidized Low-Density Lipoprotein/ ?2-Glycoprotein I Complex Is Associated with Abdominal Obesity in Healthy Middle-Aged Men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906902" target="_blank" >RIV/00216208:11120/13:43906902 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000343049" target="_blank" >http://dx.doi.org/10.1159/000343049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000343049" target="_blank" >10.1159/000343049</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Oxidized Low-Density Lipoprotein/ ?2-Glycoprotein I Complex Is Associated with Abdominal Obesity in Healthy Middle-Aged Men

Popis výsledku v původním jazyce

Oxidized low-density lipoprotein (oxLDL) in complex with ?2-glycoprotein I (?2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/?2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/?2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. Methods: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. Results: The obese men demonstrated higheroxLDL/?2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/?2GPI correlated with more insulin resistance parameters compared to A

Název v anglickém jazyce

The Oxidized Low-Density Lipoprotein/ ?2-Glycoprotein I Complex Is Associated with Abdominal Obesity in Healthy Middle-Aged Men

Popis výsledku anglicky

Oxidized low-density lipoprotein (oxLDL) in complex with ?2-glycoprotein I (?2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/?2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/?2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. Methods: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. Results: The obese men demonstrated higheroxLDL/?2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/?2GPI correlated with more insulin resistance parameters compared to A

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Nutrition and Metabolism

ISSN

0250-6807

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

7-13

Kód UT WoS článku

000314620900002

EID výsledku v databázi Scopus

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