Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43915727" target="_blank" >RIV/00216208:11120/18:43915727 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/18:N0000031

Výsledek na webu

<a href="https://doi.org/10.1038/ijo.2017.260" target="_blank" >https://doi.org/10.1038/ijo.2017.260</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ijo.2017.260" target="_blank" >10.1038/ijo.2017.260</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese

Popis výsledku v původním jazyce

BACKGROUND/OBJECTIVES: OxLDL-β2GPI complex has been suggested to play a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development. SUBJECTS/METHODS: Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of BMI (17-48 kg/m(2)) and metabolic status (with or without metabolic syndrome (MS); Cohort II: 20 obese women undergoing a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL-β2GPI were measured by ELISA. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and HOMA-IR. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in Cohort I and in SAT in Cohort II. RESULTS: Serum oxLDL- β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6+-5.0 vs lean: 15.17+-1.97, P&lt;0.001; vs obese without MS: 16.36+-2.89, P&lt;0.05). Serum oxLDL-β2GPI correlated with MS indices (glucose, HDL, TG, ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing dietary intervention decreased serum oxLDL-β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT. CONCLUSION: OxLDL-β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.

Název v anglickém jazyce

Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese

Popis výsledku anglicky

BACKGROUND/OBJECTIVES: OxLDL-β2GPI complex has been suggested to play a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development. SUBJECTS/METHODS: Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of BMI (17-48 kg/m(2)) and metabolic status (with or without metabolic syndrome (MS); Cohort II: 20 obese women undergoing a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL-β2GPI were measured by ELISA. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and HOMA-IR. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in Cohort I and in SAT in Cohort II. RESULTS: Serum oxLDL- β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6+-5.0 vs lean: 15.17+-1.97, P&lt;0.001; vs obese without MS: 16.36+-2.89, P&lt;0.05). Serum oxLDL-β2GPI correlated with MS indices (glucose, HDL, TG, ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing dietary intervention decreased serum oxLDL-β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT. CONCLUSION: OxLDL-β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/GA16-14048S" target="_blank" >GA16-14048S: Limitovaná expandabilita tukové tkáně jako rizikový faktor rozvoje diabetu 2.typu: role preadipocytů (LIMEX)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Obesity

ISSN

0307-0565

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

405-411

Kód UT WoS článku

000428844600017

EID výsledku v databázi Scopus

2-s2.0-85044578697