Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908016" target="_blank" >RIV/00216208:11120/14:43908016 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1210/jc.2013-3348" target="_blank" >http://dx.doi.org/10.1210/jc.2013-3348</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2013-3348" target="_blank" >10.1210/jc.2013-3348</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction

Popis výsledku v původním jazyce

Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examinedin the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels o

Název v anglickém jazyce

Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction

Popis výsledku anglicky

Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examinedin the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Endocrinology and Metabolism

ISSN

0021-972X

e-ISSN

—

Svazek periodika

99

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"E528"-"E535"

Kód UT WoS článku

000333461600019

EID výsledku v databázi Scopus

—