Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906988" target="_blank" >RIV/00216208:11120/13:43906988 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/13:00426449 RIV/61383082:_____/13:0034

Výsledek na webu

<a href="http://dx.doi.org/10.1111/imm.12007" target="_blank" >http://dx.doi.org/10.1111/imm.12007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/imm.12007" target="_blank" >10.1111/imm.12007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Popis výsledku v původním jazyce

Several studies have documented that dietary modifications influence the development of type 1 diabetes. However, little is known about the interplay of dietary components and the penetration of diabetes incidence. In this study we tested if wheat glutenis able to induce differences in the cytokine pattern of Foxp3+ regulatory T cells, as well as Foxp3- T cells, isolated from intestinal mucosal lymphoid tissue and non-mucosal lymphoid compartments in BALB/c mice. The gluten-containing standard diet markedly changed the cytokine expression within Foxp3- T cells, in all lymphoid organs tested, towards a higher expression of pro-inflammatory interferon-? (IFN-?), interleukin-17 (IL-17) and IL-2. In Foxp3+ regulatory T cells, gluten ingestion resulted ina mucosal increase in IL-17 and IL-2 and an overall increase in IFN-? and IL-4. The gluten-free diet induced an anti-inflammatory cytokine profile with higher proportion of transforming growth factor-beta (TGF-beta)+Foxp3- T cells in all

Název v anglickém jazyce

Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice

Popis výsledku anglicky

Several studies have documented that dietary modifications influence the development of type 1 diabetes. However, little is known about the interplay of dietary components and the penetration of diabetes incidence. In this study we tested if wheat glutenis able to induce differences in the cytokine pattern of Foxp3+ regulatory T cells, as well as Foxp3- T cells, isolated from intestinal mucosal lymphoid tissue and non-mucosal lymphoid compartments in BALB/c mice. The gluten-containing standard diet markedly changed the cytokine expression within Foxp3- T cells, in all lymphoid organs tested, towards a higher expression of pro-inflammatory interferon-? (IFN-?), interleukin-17 (IL-17) and IL-2. In Foxp3+ regulatory T cells, gluten ingestion resulted ina mucosal increase in IL-17 and IL-2 and an overall increase in IFN-? and IL-4. The gluten-free diet induced an anti-inflammatory cytokine profile with higher proportion of transforming growth factor-beta (TGF-beta)+Foxp3- T cells in all

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunology

ISSN

0019-2805

e-ISSN

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Svazek periodika

138

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

23-33

Kód UT WoS článku

000312537100003

EID výsledku v databázi Scopus

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