Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907095" target="_blank" >RIV/00216208:11120/13:43907095 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/13:43914259 RIV/00216208:11510/13:10247493

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000338405" target="_blank" >http://dx.doi.org/10.1159/000338405</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000338405" target="_blank" >10.1159/000338405</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

Popis výsledku v původním jazyce

Background/Aims: Central dopaminergic activity is probably linked to regulation of glucose and lipid metabolism and weight maintenance. The aim of our study was to evaluate the relationship between central dopaminergic activity measured using the apomorphine challenge test and metabolic parameters in healthy men. Methods: Forty-two healthy men (average age 43.5 ? 7.4 years, body mass index, BMI, 27.4 ? 5.7) were examined anthropometrically and biochemically (glycemia, lipids, glycated hemoglobin). Central dopaminergic activity was assessed as the area under the curve (AUC) of prolactin (PRL) and growth hormone (GH) responses to the apomorphine challenge test after sublingual administration of apomorphine in a dose of 0.033 mg/kg. Insulin resistance wasquantified by calculation of glucose disposal and metabolic clearance rate during a euglycemic hyperinsulinemic clamp on two insulin levels (1 and 10 mIU/kg/min). Linear regression was used for statistical analysis. Results: Hormonal res

Název v anglickém jazyce

Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

Popis výsledku anglicky

Background/Aims: Central dopaminergic activity is probably linked to regulation of glucose and lipid metabolism and weight maintenance. The aim of our study was to evaluate the relationship between central dopaminergic activity measured using the apomorphine challenge test and metabolic parameters in healthy men. Methods: Forty-two healthy men (average age 43.5 ? 7.4 years, body mass index, BMI, 27.4 ? 5.7) were examined anthropometrically and biochemically (glycemia, lipids, glycated hemoglobin). Central dopaminergic activity was assessed as the area under the curve (AUC) of prolactin (PRL) and growth hormone (GH) responses to the apomorphine challenge test after sublingual administration of apomorphine in a dose of 0.033 mg/kg. Insulin resistance wasquantified by calculation of glucose disposal and metabolic clearance rate during a euglycemic hyperinsulinemic clamp on two insulin levels (1 and 10 mIU/kg/min). Linear regression was used for statistical analysis. Results: Hormonal res

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrionology

ISSN

0028-3835

e-ISSN

—

Svazek periodika

97

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

132-138

Kód UT WoS článku

000316737000002

EID výsledku v databázi Scopus

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