The Reversibility of UV-B Induced Alterations in Optical Properties of the Rabbit Cornea Depends on Dose of UV Irradiation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907250" target="_blank" >RIV/00216208:11120/13:43907250 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/13:00390181 RIV/61389013:_____/13:00390181 RIV/68407700:21460/13:00202593 RIV/00216208:11130/13:10209771 RIV/00064203:_____/13:10209771
Výsledek na webu
<a href="http://dx.doi.org/10.1111/php.12010" target="_blank" >http://dx.doi.org/10.1111/php.12010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/php.12010" target="_blank" >10.1111/php.12010</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Reversibility of UV-B Induced Alterations in Optical Properties of the Rabbit Cornea Depends on Dose of UV Irradiation
Popis výsledku v původním jazyce
Solar UVB radiation evokes photokeratitis, accompanied by increased corneal hydration and changes in corneal transparency, resulting in increased light absorption. Corneal optical properties are disturbed and visual acuity decreased. The aim of this study was to investigate the reversibility of these UVB-induced changes. Rabbit corneas were irradiated with UVB doses of 0.5Jcm2 or 1.01Jcm2 during 4days. Some rabbits were sacrificed after the last irradiation and some 2months later. Corneas were investigated spectrophotometrically for light absorption, and corneal hydration was evaluated by central corneal thickness with an ultrasonic pachymeter. Corneal impression cytologies were examined immunohistochemically for proinflammatory cytokines and malondialdehyde. The increased corneal light absorption, hydration and the staining of immunohistochemical markers found in corneas after irradiation returned to normal values during 2months in corneas irradiated with the lower UVB dose. In contra
Název v anglickém jazyce
The Reversibility of UV-B Induced Alterations in Optical Properties of the Rabbit Cornea Depends on Dose of UV Irradiation
Popis výsledku anglicky
Solar UVB radiation evokes photokeratitis, accompanied by increased corneal hydration and changes in corneal transparency, resulting in increased light absorption. Corneal optical properties are disturbed and visual acuity decreased. The aim of this study was to investigate the reversibility of these UVB-induced changes. Rabbit corneas were irradiated with UVB doses of 0.5Jcm2 or 1.01Jcm2 during 4days. Some rabbits were sacrificed after the last irradiation and some 2months later. Corneas were investigated spectrophotometrically for light absorption, and corneal hydration was evaluated by central corneal thickness with an ultrasonic pachymeter. Corneal impression cytologies were examined immunohistochemically for proinflammatory cytokines and malondialdehyde. The increased corneal light absorption, hydration and the staining of immunohistochemical markers found in corneas after irradiation returned to normal values during 2months in corneas irradiated with the lower UVB dose. In contra
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
BO - Biofyzika
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Photochemistry and Photobiology
ISSN
0031-8655
e-ISSN
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Svazek periodika
89
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
474-482
Kód UT WoS článku
000315644100026
EID výsledku v databázi Scopus
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