Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908150" target="_blank" >RIV/00216208:11120/14:43908150 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/14:10210611 RIV/00064203:_____/14:10210611

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcf.2013.06.003" target="_blank" >http://dx.doi.org/10.1016/j.jcf.2013.06.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcf.2013.06.003" target="_blank" >10.1016/j.jcf.2013.06.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations

Popis výsledku v původním jazyce

In recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague). Methods: We evaluated the effect of elevating the IRT-cut-off from 50 to 65 mu g/l (similar to 97.5th to similar to 99.0th percentile), the need of a failsafe protocol (FS, lRT >= 99.9th percentile) and the relative performance using either two lRT-dependent PAP-cut-offs or one PAP-cut-off. Findings: Elevation of the IRT cut-off to 65 mu g/l (similar to 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p <0.0001, Prague: 0.052 vs. 0.074, p <0.0001) without reducing sensitivity.All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs. Conclusions: For best performance we suggest an IRT/PAP protocol with

Název v anglickém jazyce

Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations

Popis výsledku anglicky

In recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague). Methods: We evaluated the effect of elevating the IRT-cut-off from 50 to 65 mu g/l (similar to 97.5th to similar to 99.0th percentile), the need of a failsafe protocol (FS, lRT >= 99.9th percentile) and the relative performance using either two lRT-dependent PAP-cut-offs or one PAP-cut-off. Findings: Elevation of the IRT cut-off to 65 mu g/l (similar to 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p <0.0001, Prague: 0.052 vs. 0.074, p <0.0001) without reducing sensitivity.All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs. Conclusions: For best performance we suggest an IRT/PAP protocol with

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cystic Fibrosis

ISSN

1569-1993

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

15-23

Kód UT WoS článku

000329951600003

EID výsledku v databázi Scopus

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