Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909408" target="_blank" >RIV/00216208:11120/15:43909408 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/15:43914530

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biopsych.2013.11.007" target="_blank" >http://dx.doi.org/10.1016/j.biopsych.2013.11.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopsych.2013.11.007" target="_blank" >10.1016/j.biopsych.2013.11.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders

Popis výsledku v původním jazyce

Background: Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages the brain and frequently co-occurs with BD. Studying patients with both T2DM and BD could helpidentify preventable risk factors for neuroimaging changes in BD. Methods: We used 1.5T magnetic resonance spectroscopy to measure prefrontal N-acetylaspartate (NAA), which is mainly localized in neurons, and total creatine (tCr), an energy metabolite,in 19 BD patients with insulin resistance/glucose intolerance (BD + IR/GI), 14 BD subjects with T2DM (BD + T2DM), 15 euglycemic BD participants, and 11 euglycemic, nonpsychiatric control. Results: The levels of NAA and tCr were lowest among BD + T2DM, intermediate in the BD + IR/GI, and highest among the euglycemic BD and control subjects (F3,55 = 4.57, p = .006; F3,55 = 2.92, p = .04, respectively). Even the BD + IR/GI subjects had lower NAA than the euglycemic participants (t43 = 2.13,

Název v anglickém jazyce

Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders

Popis výsledku anglicky

Background: Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages the brain and frequently co-occurs with BD. Studying patients with both T2DM and BD could helpidentify preventable risk factors for neuroimaging changes in BD. Methods: We used 1.5T magnetic resonance spectroscopy to measure prefrontal N-acetylaspartate (NAA), which is mainly localized in neurons, and total creatine (tCr), an energy metabolite,in 19 BD patients with insulin resistance/glucose intolerance (BD + IR/GI), 14 BD subjects with T2DM (BD + T2DM), 15 euglycemic BD participants, and 11 euglycemic, nonpsychiatric control. Results: The levels of NAA and tCr were lowest among BD + T2DM, intermediate in the BD + IR/GI, and highest among the euglycemic BD and control subjects (F3,55 = 4.57, p = .006; F3,55 = 2.92, p = .04, respectively). Even the BD + IR/GI subjects had lower NAA than the euglycemic participants (t43 = 2.13,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological Psychiatry

ISSN

0006-3223

e-ISSN

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Svazek periodika

77

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

295-303

Kód UT WoS článku

000346845500018

EID výsledku v databázi Scopus

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