Frequency discrimination in rats exposed to noise as juveniles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909446" target="_blank" >RIV/00216208:11120/15:43909446 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/15:00452448

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.physbeh.2015.03.005" target="_blank" >http://dx.doi.org/10.1016/j.physbeh.2015.03.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.physbeh.2015.03.005" target="_blank" >10.1016/j.physbeh.2015.03.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Frequency discrimination in rats exposed to noise as juveniles

Popis výsledku v původním jazyce

Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long-Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3-5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85-90 dB SPL. Our data suggests that brief noise

Název v anglickém jazyce

Frequency discrimination in rats exposed to noise as juveniles

Popis výsledku anglicky

Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long-Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3-5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85-90 dB SPL. Our data suggests that brief noise

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiology &amp; Behavior

ISSN

0031-9384

e-ISSN

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Svazek periodika

144

Číslo periodika v rámci svazku

May 15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

60-65

Kód UT WoS článku

000353751900008

EID výsledku v databázi Scopus

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