Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909616" target="_blank" >RIV/00216208:11120/15:43909616 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/15:#0000476

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijcard.2015.03.398" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2015.03.398</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2015.03.398" target="_blank" >10.1016/j.ijcard.2015.03.398</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

Popis výsledku v původním jazyce

Atherosclerosis (AS) is a chronic inflammatory lipid-storage disease of the large arteries. In addition to the key role of cholesterol homeostasis, both innate and adaptive immunity contribute to the evolution of the disease and its complications. Lipidantigens are recognized by Invariant Natural Killer T (iNKT) cells. iNKT cells are called unconventional T cells as they express markers of both T and NK cell lineages and exert rapidly effector functions. iNKT cells produce both pro-inflammatory and regulatory cytokines, harbor cytolytic potential and actively interact with other cells of the immune system. Due to their vast functional potential, iNKT cells are involved in the pathogenesis of various pathologic conditions including cancer, infection and autoimmune diseases. In conclusion, we suggest that iNKT cells play a pathogenic role in human atherosclerosis due to the promotion of inflammation. This is reflected and might even be mediated by fine tuning of NK receptors

Název v anglickém jazyce

Potential role of invariant natural killer T cells in outcomes of acute myocardial infarction

Popis výsledku anglicky

Atherosclerosis (AS) is a chronic inflammatory lipid-storage disease of the large arteries. In addition to the key role of cholesterol homeostasis, both innate and adaptive immunity contribute to the evolution of the disease and its complications. Lipidantigens are recognized by Invariant Natural Killer T (iNKT) cells. iNKT cells are called unconventional T cells as they express markers of both T and NK cell lineages and exert rapidly effector functions. iNKT cells produce both pro-inflammatory and regulatory cytokines, harbor cytolytic potential and actively interact with other cells of the immune system. Due to their vast functional potential, iNKT cells are involved in the pathogenesis of various pathologic conditions including cancer, infection and autoimmune diseases. In conclusion, we suggest that iNKT cells play a pathogenic role in human atherosclerosis due to the promotion of inflammation. This is reflected and might even be mediated by fine tuning of NK receptors

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

187

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

3

Strana od-do

663-665

Kód UT WoS článku

000354905600175

EID výsledku v databázi Scopus

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