Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909887" target="_blank" >RIV/00216208:11120/15:43909887 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/15:00446320 RIV/00216208:11310/15:10321607

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bbr.2015.07.001" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2015.07.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2015.07.001" target="_blank" >10.1016/j.bbr.2015.07.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Popis výsledku v původním jazyce

The aim of the present study was an evaluation of prenatal exposure to acute methamphetamine (MA) treatment on manifestations of anxiety. Anxiety was evaluated in adult animals in three different experimental models: the Elevated plus-maze (EPM), Socialinteraction test (SIT) and Ultrasound vocalization (USV). Female rats were administered saline (S) or MA (5mg/kg) daily throughout their entire gestation period. The male progeny, in adulthood, were administered with challenge dose of S or MA (1mg/kg) prior to evaluation of anxiety. The study demonstrated that prenatal MA exposure increased the anxiogenic effect on evaluated behaviour patterns in the USV model and to a lesser degree in the EPM model. In addition, the acute MA challenge in adulthood decreased the time spent during social interaction suggesting an anxiogenic effect in the SIT model as well. On the other hand, some of the evaluated parameters (e.g., the number of head-dipping in the EPM and number of dropped boluses in the

Název v anglickém jazyce

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Popis výsledku anglicky

The aim of the present study was an evaluation of prenatal exposure to acute methamphetamine (MA) treatment on manifestations of anxiety. Anxiety was evaluated in adult animals in three different experimental models: the Elevated plus-maze (EPM), Socialinteraction test (SIT) and Ultrasound vocalization (USV). Female rats were administered saline (S) or MA (5mg/kg) daily throughout their entire gestation period. The male progeny, in adulthood, were administered with challenge dose of S or MA (1mg/kg) prior to evaluation of anxiety. The study demonstrated that prenatal MA exposure increased the anxiogenic effect on evaluated behaviour patterns in the USV model and to a lesser degree in the EPM model. In addition, the acute MA challenge in adulthood decreased the time spent during social interaction suggesting an anxiogenic effect in the SIT model as well. On the other hand, some of the evaluated parameters (e.g., the number of head-dipping in the EPM and number of dropped boluses in the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

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Svazek periodika

292

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

361-369

Kód UT WoS článku

000361583500042

EID výsledku v databázi Scopus

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