Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43910374" target="_blank" >RIV/00216208:11120/15:43910374 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/15:00446509 RIV/00023001:_____/15:00059511 RIV/00064190:_____/15:#0001077
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2015/385395" target="_blank" >http://dx.doi.org/10.1155/2015/385395</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/385395" target="_blank" >10.1155/2015/385395</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
Popis výsledku v původním jazyce
Reduced beta cell mass in pancreatic islets (PI) of Goto-Kakizaki (GK) rats is frequently observed in this diabetic model, but knowledge on delta cells is scarce. Aiming to compare delta cell physiology/pathology of GK to Wistar rats, we found that deltacell number increased over time as did somatostatin mRNA and delta cells distribution in PI is different in GK rats. Subtle changes in 6-week-old GK rats were found. With maturation and aging of GK rats, disturbed cytoarchitecture occurred with irregular beta cells accompanied by delta cell hyperplasia and loss of pancreatic polypeptide (PPY) positivity. Unlike the constant glucose-stimulation index for insulin PI release in Wistar rats, this index declined with GK age, whereas for somatostatin it increased with age. A decrease of GK rat PPY serum levels was found. GK rat body weight decreased with increasing hyperglycemia. Somatostatin analog octreotide completely blocked insulin secretion, impaired proliferation at low autocrine insu
Název v anglickém jazyce
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
Popis výsledku anglicky
Reduced beta cell mass in pancreatic islets (PI) of Goto-Kakizaki (GK) rats is frequently observed in this diabetic model, but knowledge on delta cells is scarce. Aiming to compare delta cell physiology/pathology of GK to Wistar rats, we found that deltacell number increased over time as did somatostatin mRNA and delta cells distribution in PI is different in GK rats. Subtle changes in 6-week-old GK rats were found. With maturation and aging of GK rats, disturbed cytoarchitecture occurred with irregular beta cells accompanied by delta cell hyperplasia and loss of pancreatic polypeptide (PPY) positivity. Unlike the constant glucose-stimulation index for insulin PI release in Wistar rats, this index declined with GK age, whereas for somatostatin it increased with age. A decrease of GK rat PPY serum levels was found. GK rat body weight decreased with increasing hyperglycemia. Somatostatin analog octreotide completely blocked insulin secretion, impaired proliferation at low autocrine insu
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-06666S" target="_blank" >GA13-06666S: Morfologie a funkce mitochondrií ß-buněk pankreatu v patogenezi diabetu 2. typu</a><br>
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Diabetes Research
ISSN
2314-6745
e-ISSN
—
Svazek periodika
2015
Číslo periodika v rámci svazku
Article ID 385395
Stát vydavatele periodika
EG - Egyptská arabská republika
Počet stran výsledku
16
Strana od-do
1-16
Kód UT WoS článku
000358227300001
EID výsledku v databázi Scopus
—