High flow nasal cannula versus NCPAP, duration to full oral feeds in preterm infants: a randomised controlled trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912650" target="_blank" >RIV/00216208:11120/17:43912650 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1136/archdischild-2016-311388" target="_blank" >http://dx.doi.org/10.1136/archdischild-2016-311388</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/archdischild-2016-311388" target="_blank" >10.1136/archdischild-2016-311388</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High flow nasal cannula versus NCPAP, duration to full oral feeds in preterm infants: a randomised controlled trial

Popis výsledku v původním jazyce

OBJECTIVE: To compare the time taken by preterm infants with evolving chronic lung disease to achieve full oral feeding when supported with humidified high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP). DESIGN: Single centre randomised controlled trial. SETTING: Level III neonatal intensive care unit at the Coombe Women and Infants University Hospital, Dublin, Ireland. PATIENTS: Very low birthweight (birth weight &lt;1500 g) infants born before 30 weeks&apos; gestation who were NCPAP-dependent at 32 weeks corrected gestational age were eligible to participate. INTERVENTIONS: Enrolled infants were randomised in a 1:1 ratio to receive HFNC or NCPAP. Participants were monitored daily until full oral feeding was established and the baby was off respiratory support. MAIN OUTCOME MEASURES: Our primary outcome was the number of days taken to establish full oral feeds (defined as oral intake GREATER-THAN OR EQUAL TO120 mL/kg/day) from the time of randomisation. We estimated that enrolling 44 subjects (22 in each group) would allow us demonstrate a 7-day difference in our primary outcome with 80% power and α of 5%. RESULTS: Forty-four infants were randomised (22 to HFNC vs 22 to NCPAP). The mean time to achieve full oral feeding was not different between the groups (HFNC 36.5 (+-18.2) days vs NCPAP 34.1 (+-11.2) days, p=0.61). CONCLUSIONS: Preterm infants treated with HFNC did not achieve full oral feeding more quickly than infants treated with NCPAP.

Název v anglickém jazyce

High flow nasal cannula versus NCPAP, duration to full oral feeds in preterm infants: a randomised controlled trial

Popis výsledku anglicky

OBJECTIVE: To compare the time taken by preterm infants with evolving chronic lung disease to achieve full oral feeding when supported with humidified high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP). DESIGN: Single centre randomised controlled trial. SETTING: Level III neonatal intensive care unit at the Coombe Women and Infants University Hospital, Dublin, Ireland. PATIENTS: Very low birthweight (birth weight &lt;1500 g) infants born before 30 weeks&apos; gestation who were NCPAP-dependent at 32 weeks corrected gestational age were eligible to participate. INTERVENTIONS: Enrolled infants were randomised in a 1:1 ratio to receive HFNC or NCPAP. Participants were monitored daily until full oral feeding was established and the baby was off respiratory support. MAIN OUTCOME MEASURES: Our primary outcome was the number of days taken to establish full oral feeds (defined as oral intake GREATER-THAN OR EQUAL TO120 mL/kg/day) from the time of randomisation. We estimated that enrolling 44 subjects (22 in each group) would allow us demonstrate a 7-day difference in our primary outcome with 80% power and α of 5%. RESULTS: Forty-four infants were randomised (22 to HFNC vs 22 to NCPAP). The mean time to achieve full oral feeding was not different between the groups (HFNC 36.5 (+-18.2) days vs NCPAP 34.1 (+-11.2) days, p=0.61). CONCLUSIONS: Preterm infants treated with HFNC did not achieve full oral feeding more quickly than infants treated with NCPAP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Disease in Childhood: Fetal and Neonatal Edition

ISSN

1359-2998

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

"F329"-"F332"

Kód UT WoS článku

000405257300009

EID výsledku v databázi Scopus

2-s2.0-85021049251