Glutamate Transporters (EAAT-1-3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920497" target="_blank" >RIV/00216208:11120/20:43920497 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/20:43920300

Výsledek na webu

<a href="https://doi.org/10.1007/s11055-020-00965-4" target="_blank" >https://doi.org/10.1007/s11055-020-00965-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11055-020-00965-4" target="_blank" >10.1007/s11055-020-00965-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Glutamate Transporters (EAAT-1-3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy

Popis výsledku v původním jazyce

Epilepsy is one of the commonest neurological diseases, though convulsive seizures cannot be completely cured in 30% of patients, such that there is a need to develop new pharmacological approaches to its treatment. In some pathological states, including drug-resistant forms of epilepsy, the mechanisms removing glutamate from the synaptic cleft may be impaired, so one potential approach to these pathological states may be associated with actions on glutamate transporters. The present review analyzes contemporary data on changes in the expression of excitatory amino acid transporter proteins (EAAT) in human epilepsy and in animal models of convulsive states and epilepsy. Mechanisms of actions on the expression and activity of transporters as potential therapeutic targets for the treatment of convulsive states are considered, special attention being paid to analysis of the use of the antibiotic ceftriaxone, which increases the expression and activity of EAAT-2.

Název v anglickém jazyce

Glutamate Transporters (EAAT-1-3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy

Popis výsledku anglicky

Epilepsy is one of the commonest neurological diseases, though convulsive seizures cannot be completely cured in 30% of patients, such that there is a need to develop new pharmacological approaches to its treatment. In some pathological states, including drug-resistant forms of epilepsy, the mechanisms removing glutamate from the synaptic cleft may be impaired, so one potential approach to these pathological states may be associated with actions on glutamate transporters. The present review analyzes contemporary data on changes in the expression of excitatory amino acid transporter proteins (EAAT) in human epilepsy and in animal models of convulsive states and epilepsy. Mechanisms of actions on the expression and activity of transporters as potential therapeutic targets for the treatment of convulsive states are considered, special attention being paid to analysis of the use of the antibiotic ceftriaxone, which increases the expression and activity of EAAT-2.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience and Behavioral Physiology

ISSN

0097-0549

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

777-786

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85090215720