Applicability of large-area single-photon counting detectors Timepix for high-resolution and high-contrast X-ray imaging of biological samples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43922781" target="_blank" >RIV/00216208:11120/22:43922781 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/22:10436711 RIV/68407700:21670/22:00355014

Výsledek na webu

<a href="https://doi.org/10.1109/TNS.2022.3140396" target="_blank" >https://doi.org/10.1109/TNS.2022.3140396</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/TNS.2022.3140396" target="_blank" >10.1109/TNS.2022.3140396</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Applicability of large-area single-photon counting detectors Timepix for high-resolution and high-contrast X-ray imaging of biological samples

Popis výsledku v původním jazyce

High-resolution X-ray imaging techniques, usually known as micro-radiography and micro-CT, have become highly required and frequently used tools for biology, biomedical and preclinical research. State-of-the-art micro-CT scanners are capable of achieving a spatial resolution of few micrometers or even less thanks to the constant development of compact microfocus X-ray sources together with simultaneous progress in detector technologies. The current standard in X-ray detection is a digital imaging device containing read-out circuitry coupled with a scintillation sensor. Such detectors are available in a variety of different sizes, easy to use and relatively affordable. Nevertheless, the mentioned technology suffers from inherent limitations like, for example, undesirable generation of dark current, that compromise the quality of the provided data. This work demonstrates the applicability of Timepix large-area hybrid-pixel photon-counting detectors for high-resolution X-ray imaging in biology research. Photon-counting detection technology provides dark-current-free quantum-counting operation. Therefore, an enhanced contrast-to-noise ratio of the acquired data is achieved. Furthermore, the biased semiconductor sensor achieves almost ideal point-spread-function resulting in images with high spatial-resolution. Both above-mentioned features make photon-counting detectors to be excellent tools for high-resolution X-ray imaging especially for samples with low intrinsic absorption contrast. We evaluated the imaging performance of large-area Timepix detectors compared to a state-of-the-art flat-panel detector dedicated for high-resolution X-ray imaging. The presented data demonstrate the versatility of the used detectors as it covers a wide range of samples from laboratory animals to single-cell marine organisms.

Název v anglickém jazyce

Applicability of large-area single-photon counting detectors Timepix for high-resolution and high-contrast X-ray imaging of biological samples

Popis výsledku anglicky

High-resolution X-ray imaging techniques, usually known as micro-radiography and micro-CT, have become highly required and frequently used tools for biology, biomedical and preclinical research. State-of-the-art micro-CT scanners are capable of achieving a spatial resolution of few micrometers or even less thanks to the constant development of compact microfocus X-ray sources together with simultaneous progress in detector technologies. The current standard in X-ray detection is a digital imaging device containing read-out circuitry coupled with a scintillation sensor. Such detectors are available in a variety of different sizes, easy to use and relatively affordable. Nevertheless, the mentioned technology suffers from inherent limitations like, for example, undesirable generation of dark current, that compromise the quality of the provided data. This work demonstrates the applicability of Timepix large-area hybrid-pixel photon-counting detectors for high-resolution X-ray imaging in biology research. Photon-counting detection technology provides dark-current-free quantum-counting operation. Therefore, an enhanced contrast-to-noise ratio of the acquired data is achieved. Furthermore, the biased semiconductor sensor achieves almost ideal point-spread-function resulting in images with high spatial-resolution. Both above-mentioned features make photon-counting detectors to be excellent tools for high-resolution X-ray imaging especially for samples with low intrinsic absorption contrast. We evaluated the imaging performance of large-area Timepix detectors compared to a state-of-the-art flat-panel detector dedicated for high-resolution X-ray imaging. The presented data demonstrate the versatility of the used detectors as it covers a wide range of samples from laboratory animals to single-cell marine organisms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/EF16_019%2F0000766" target="_blank" >EF16_019/0000766: Inženýrské aplikace fyziky mikrosvěta</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IEEE Transactions on Nuclear Science

ISSN

0018-9499

e-ISSN

1558-1578

Svazek periodika

69

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

753-760

Kód UT WoS článku

000803113800024

EID výsledku v databázi Scopus

2-s2.0-85122569860