Trafficking of Neuronal Calcium Channels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43924207" target="_blank" >RIV/00216208:11120/22:43924207 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/978-3-031-08881-0_8" target="_blank" >https://doi.org/10.1007/978-3-031-08881-0_8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-08881-0_8" target="_blank" >10.1007/978-3-031-08881-0_8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Trafficking of Neuronal Calcium Channels

Popis výsledku v původním jazyce

Neuronal voltage-gated calcium channels (VGCCs) serve a wide range of complex yet critical physiological functions by converting electrical signals into intracellular calcium increase and subsequent activation of downstream signaling pathways. The magnitude to which VGCCs affect neuronal activities largely depends on their density in the plasma membrane. Ectopic expression at the cell surface can lead to severe neurological conditions. Hence, numerous efforts have been dedicated to identifying the molecular mechanisms underlying the regulation of VGCCs which has led to the discovery of several interacting proteins and posttranslational modifications that contribute to their trafficking to and from the plasma membrane. In this chapter, we synthesize the current state of knowledge of these underlying mechanisms that drive the expression of VGCCs at the plasma membrane and address their implications in pathophysiological circumstances, and their potential as therapeutic targets.

Název v anglickém jazyce

Trafficking of Neuronal Calcium Channels

Popis výsledku anglicky

Neuronal voltage-gated calcium channels (VGCCs) serve a wide range of complex yet critical physiological functions by converting electrical signals into intracellular calcium increase and subsequent activation of downstream signaling pathways. The magnitude to which VGCCs affect neuronal activities largely depends on their density in the plasma membrane. Ectopic expression at the cell surface can lead to severe neurological conditions. Hence, numerous efforts have been dedicated to identifying the molecular mechanisms underlying the regulation of VGCCs which has led to the discovery of several interacting proteins and posttranslational modifications that contribute to their trafficking to and from the plasma membrane. In this chapter, we synthesize the current state of knowledge of these underlying mechanisms that drive the expression of VGCCs at the plasma membrane and address their implications in pathophysiological circumstances, and their potential as therapeutic targets.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GA22-23242S" target="_blank" >GA22-23242S: Fyzio(pato)logie vápníkových kanálů typu T v souvislosti s funkcí motorických neuronů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Voltage-Gated Calcium Channels

ISBN

978-3-031-08880-3

Počet stran výsledku

22

Strana od-do

195-216

Počet stran knihy

710

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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