Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00474256" target="_blank" >RIV/61388963:_____/17:00474256 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4149/gpb_2016037" target="_blank" >http://dx.doi.org/10.4149/gpb_2016037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2016037" target="_blank" >10.4149/gpb_2016037</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Popis výsledku v původním jazyce

Recent findings have revealed a fundamental role of the ubiquitin-proteasome system (UPS) in the regulation of voltage-gated Ca2+ channels (VGCCs). It has been proposed that the ubiquitination-deubiquitination balance dictates the number of channels expressed at the plasma membrane, which in turn influences a number of physiological and pathophysiological processes. This minireview surveys recent studies showing that VGCCs may be ubiquitinated in an unexpectedly complex manner, and highlights the role of the UPS in the regulation of the channels, focusing on the mechanisms that control their cell surface expression. The exciting new findings in this emerging field suggest that the turnover of VGCCs may be determined to a large degree by the activity of the UPS, and that alteration of the UPS molecular machinery may be one of the underlying mechanisms occurring in a number of channelopathies.

Název v anglickém jazyce

Ubiquitination and proteasome-mediated degradation of voltage-gated Ca2+ channels and potential pathophysiological implications

Popis výsledku anglicky

Recent findings have revealed a fundamental role of the ubiquitin-proteasome system (UPS) in the regulation of voltage-gated Ca2+ channels (VGCCs). It has been proposed that the ubiquitination-deubiquitination balance dictates the number of channels expressed at the plasma membrane, which in turn influences a number of physiological and pathophysiological processes. This minireview surveys recent studies showing that VGCCs may be ubiquitinated in an unexpectedly complex manner, and highlights the role of the UPS in the regulation of the channels, focusing on the mechanisms that control their cell surface expression. The exciting new findings in this emerging field suggest that the turnover of VGCCs may be determined to a large degree by the activity of the UPS, and that alteration of the UPS molecular machinery may be one of the underlying mechanisms occurring in a number of channelopathies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

1-5

Kód UT WoS článku

000392164100001

EID výsledku v databázi Scopus

2-s2.0-85021857536