Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F98%3A43896440" target="_blank" >RIV/00216208:11120/98:43896440 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/S0006-8993(98)00367-9" target="_blank" >http://dx.doi.org/10.1016/S0006-8993(98)00367-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/S0006-8993(98)00367-9" target="_blank" >10.1016/S0006-8993(98)00367-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility

Popis výsledku v původním jazyce

The present study examined the ovarian hormonal regulation of seizure susceptibility in prenatally morphine- and saline-exposed adult female rats in the flurothyl seizure model in vivo, and in low-magnesium-induced epileptiform activity in brain slices, in vitro. All females were ovariohysterectomized (OVX); some received either estrogen (E) or progesterone (P) replacement, while others were injected with E + P sequentially. In prenatally saline-treated control females, there was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the presence of both hormones (E + P) compared to OVX controls. In morphine-exposed females, there was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone while there was a reduced tonic-clonic seizure threshold in the presence of both hormones (E + P) compared to the hormone treatment-matched group of saline-exposed females, In control females, in low magnesium medium in vitro, the development of two types of epileptiform activity (seizure-like events and status of short discharges) was not affected by the different hormonal conditions. However, prenatal morphine exposure suppressed the development of both types of epileptiform activity in the E-injected females compared to the E-injected, control females. The present data demonstrate that the anticonvulsant effects of P on seizure susceptibility requires the presence of E, Furthermore, prenatal morphine exposure alters ovarian steroid hormone-regulated seizure susceptibility

Název v anglickém jazyce

Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility

Popis výsledku anglicky

The present study examined the ovarian hormonal regulation of seizure susceptibility in prenatally morphine- and saline-exposed adult female rats in the flurothyl seizure model in vivo, and in low-magnesium-induced epileptiform activity in brain slices, in vitro. All females were ovariohysterectomized (OVX); some received either estrogen (E) or progesterone (P) replacement, while others were injected with E + P sequentially. In prenatally saline-treated control females, there was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the presence of both hormones (E + P) compared to OVX controls. In morphine-exposed females, there was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone while there was a reduced tonic-clonic seizure threshold in the presence of both hormones (E + P) compared to the hormone treatment-matched group of saline-exposed females, In control females, in low magnesium medium in vitro, the development of two types of epileptiform activity (seizure-like events and status of short discharges) was not affected by the different hormonal conditions. However, prenatal morphine exposure suppressed the development of both types of epileptiform activity in the E-injected females compared to the E-injected, control females. The present data demonstrate that the anticonvulsant effects of P on seizure susceptibility requires the presence of E, Furthermore, prenatal morphine exposure alters ovarian steroid hormone-regulated seizure susceptibility

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/IZ3613" target="_blank" >IZ3613: Vliv chronické terapie antiepileptiky a časných postnatálních záchvatů na vývoj normálních mozkových funkcí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

1998

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research

ISSN

0006-8993

e-ISSN

—

Svazek periodika

796

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

247-256

Kód UT WoS článku

000074784000028

EID výsledku v databázi Scopus

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