Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7126" target="_blank" >RIV/00216208:11130/11:7126 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/11:00002526

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/22099763" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/22099763</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats

Popis výsledku v původním jazyce

Background. The transplantation of islets of Langerhans isolated from one donor pancreas can rarely release a diabetic recipient from insulin injections. The major reason is the destruction of 50%-60% of the transplanted tissue, which proceeds typicallywithin a few hours after the insertion of the islets into the portal vein. Therefore, several groups have focused on development of an artificial site for islet transplantation. The main aim of the present study was to test the efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate the blood supply feeding the artificially created cavities for islet transplantation. Methods. Two rounded devices were implanted: one device subcutaneously and the second one into the greateromentum of each animal. On the day of implantation as well as 1, 3, and 4 weeks later, we quickly injected the vascular specific MR contrast agent Vasovist (0.05 mL/100 g) intravenously. Penetration of the contrast agent was monitored by

Název v anglickém jazyce

Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Tool to Monitor the Blood Supply to an Artificial Cavity Used as a Site for Islet Transplantation in Rats

Popis výsledku anglicky

Background. The transplantation of islets of Langerhans isolated from one donor pancreas can rarely release a diabetic recipient from insulin injections. The major reason is the destruction of 50%-60% of the transplanted tissue, which proceeds typicallywithin a few hours after the insertion of the islets into the portal vein. Therefore, several groups have focused on development of an artificial site for islet transplantation. The main aim of the present study was to test the efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate the blood supply feeding the artificially created cavities for islet transplantation. Methods. Two rounded devices were implanted: one device subcutaneously and the second one into the greateromentum of each animal. On the day of implantation as well as 1, 3, and 4 weeks later, we quickly injected the vascular specific MR contrast agent Vasovist (0.05 mL/100 g) intravenously. Penetration of the contrast agent was monitored by

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP303%2F09%2FP200" target="_blank" >GP303/09/P200: Snížení exprese tkáňového faktoru buňkami izolovaných Langerhansových ostrůvků pomocí RNA interference</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

3226-3230

Kód UT WoS článku

000297485500020

EID výsledku v databázi Scopus

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