Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209622" target="_blank" >RIV/00216208:11130/13:10209622 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00394051

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nbd.2013.02.001" target="_blank" >http://dx.doi.org/10.1016/j.nbd.2013.02.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nbd.2013.02.001" target="_blank" >10.1016/j.nbd.2013.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy

Popis výsledku v původním jazyce

Temporal lobe epilepsy alters adult neurogenesis. Existing experimental evidence is mainly from chronic models induced by an initial prolonged status epilepticus associated with substantial cell death. In these models, neurogenesis increases after statusepilepticus. To test whether status epilepticus is necessary for this increase, we examined precursor cell proliferation and neurogenesis after the onset of spontaneous seizures in a model of temporal lobe epilepsy induced by unilateral intrahippocampalinjection of tetanus toxin, which does not cause status or, in most cases, detectable neuronal loss. We found a 4.5 times increase in BrdU labeling (estimating precursor cells proliferating during the 2nd week after injection of toxin and surviving at least up to 7 days) in dentate gyri of both injected and contralateral hippocampi of epileptic rats. Radiotelemetry revealed that the rats experienced 112+/-24 seizures, lasting 88+/-11 s each, over a period of 8.6+/-1.3 days from the firs

Název v anglickém jazyce

Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy

Popis výsledku anglicky

Temporal lobe epilepsy alters adult neurogenesis. Existing experimental evidence is mainly from chronic models induced by an initial prolonged status epilepticus associated with substantial cell death. In these models, neurogenesis increases after statusepilepticus. To test whether status epilepticus is necessary for this increase, we examined precursor cell proliferation and neurogenesis after the onset of spontaneous seizures in a model of temporal lobe epilepsy induced by unilateral intrahippocampalinjection of tetanus toxin, which does not cause status or, in most cases, detectable neuronal loss. We found a 4.5 times increase in BrdU labeling (estimating precursor cells proliferating during the 2nd week after injection of toxin and surviving at least up to 7 days) in dentate gyri of both injected and contralateral hippocampi of epileptic rats. Radiotelemetry revealed that the rats experienced 112+/-24 seizures, lasting 88+/-11 s each, over a period of 8.6+/-1.3 days from the firs

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/GAP303%2F10%2F0999" target="_blank" >GAP303/10/0999: Úloha oxidu dusnatého v průběhu experimentálně vyvolaných epileptických záchvatů a vzniku epilepsie u laboratorního potkana.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurobiology of Disease

ISSN

0969-9961

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

JUN 2013

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

492-498

Kód UT WoS článku

000318052000047

EID výsledku v databázi Scopus

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