Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209656" target="_blank" >RIV/00216208:11130/13:10209656 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/13:00397661
Výsledek na webu
<a href="http://dx.doi.org/10.2217/NNM.12.140" target="_blank" >http://dx.doi.org/10.2217/NNM.12.140</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/NNM.12.140" target="_blank" >10.2217/NNM.12.140</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
Popis výsledku v původním jazyce
Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factorsnecessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell na
Název v anglickém jazyce
Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use
Popis výsledku anglicky
Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factorsnecessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell na
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
BO - Biofyzika
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Nanomedicine
ISSN
1743-5889
e-ISSN
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Svazek periodika
8
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
18
Strana od-do
1137-1154
Kód UT WoS článku
000320853500017
EID výsledku v databázi Scopus
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