Time-regulated drug delivery system based on coaxially incorporated platelet alfa-granules for biomedical use

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F13%3A43921707" target="_blank" >RIV/49777513:23520/13:43921707 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2217/nnm.12.140" target="_blank" >http://dx.doi.org/10.2217/nnm.12.140</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/nnm.12.140" target="_blank" >10.2217/nnm.12.140</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Time-regulated drug delivery system based on coaxially incorporated platelet alfa-granules for biomedical use

Popis výsledku v původním jazyce

Aim: Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alfa-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing alfa-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-b1 was determined. Results: Microscopy studies showed that intact alfa-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved a-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nano

Název v anglickém jazyce

Time-regulated drug delivery system based on coaxially incorporated platelet alfa-granules for biomedical use

Popis výsledku anglicky

Aim: Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alfa-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing alfa-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-b1 was determined. Results: Microscopy studies showed that intact alfa-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved a-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nano

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomedicine

ISSN

1743-5889

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

"1137?1154"

Kód UT WoS článku

000320853500017

EID výsledku v databázi Scopus

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